Simultaneous Spectrophotometric Determination of Amitriptyline Hydrochloride and Chlordiazepoxide in Pharmaceutical Tablets by Multivariate Calibration Method
نویسندگان
چکیده
منابع مشابه
Simultaneous spectrophotometric determination of lidocaine and hydrocortisone acetate in pharmaceutical preparations by multivariate calibration methods
The multivariate calibration method, partial least square regression (PLS) was applied for thesimultaneous spectrophotometric determination of Lidocaine (LID) and Hydrocortisone acetate(HCA) in their mixtures. The parameters of chemometric technique were optimized and theproposed method was validated with synthetic samples and applied to analyze these drugs inpharmaceutical products with good a...
متن کاملSimultaneous Spectrophotometric Estimation of Imipramine Hydrochloride and Chlordiazepoxide in Tablets
A binary mixture of imipramine HCl and chlordiazepoxide was determined by three different spectrophotometric methods. The first method involved determination of imipramine HCl and chlordiazepoxide using the simultaneous equations and the second method involved absorbance ratio method. Imipramine has absorbance maxima at 251 nm, chlordiazepoxide has absorbance maxima at 264.5 nm and isoabsorptiv...
متن کاملSimultaneous Determination of Amitriptyline and Chlordiazepoxide in combined Pharmaceutical Dosage form by New RP-HPLC Method
A simple, accurate reverse phase high-performance liquid chromatographic method was developed and validated for the simultaneous estimation of Amitriptyline and Chlordiazepoxide in bulk and pharmaceutical dosage forms. Chromatography was carried out by using Chromosil C-18, column having 250 x 4.6mm internal diameter with a mixture of Methanol: Acetonitrile 70:30 (V/V) as mobile phase. Determin...
متن کاملsimultaneous spectrophotometric determination of lidocaine and hydrocortisone acetate in pharmaceutical preparations by multivariate calibration methods
the multivariate calibration method, partial least square regression (pls) was applied for thesimultaneous spectrophotometric determination of lidocaine (lid) and hydrocortisone acetate(hca) in their mixtures. the parameters of chemometric technique were optimized and theproposed method was validated with synthetic samples and applied to analyze these drugs inpharmaceutical products with good a...
متن کاملSpectrophotometric Determination of Promethazine Hydrochloride and Paracetamol in Pharmaceutical Tablets
Spectrophotometric techniques were developed for the determination of single and binarymixture Promethazine hydrochloride (PMH) and Paracetamol (PCM). Normal and first derivative (D) used for single drug at λ 249.5 and 243.0 for PMH and 243.5 and 225 for PCM. The simultaneous determination of binary mixture (PMH) and (PCM) were accomplished by first derivative (D) and second derivative (D) spec...
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ژورنال
عنوان ژورنال: E-Journal of Chemistry
سال: 2009
ISSN: 0973-4945,2090-9810
DOI: 10.1155/2009/172820